вторник, 1 ноября 2011 г.
Nine killed as Hamas clashes with Fatah
The Gaza Strip was reeling from some of the worst internecine fighting in over generic viagra viagra cialis online pharmacy pharmacy citrate year, after a Hamas raid on the stronghold of a powerful Gaza clan left at least nine dead
суббота, 29 октября 2011 г.
Tadalafil (Cialis) In The Treatment Of Erectile Dysfunction
Tadalafil (Cialis) In The Treatment Of Erectile Dysfunction
online pharmacy viagra (Cialis), one of the three available phosphodiesterase type 5 (PDE5) inhibitors that revolutionized the treatment of erectile dysfunction (ED), analyzes its latest clinical studies. Tadalafil's most unique and identifying characteristic is its long half-life of 17.5 hours, compared with 4 hours for sildenafil (Viagra) and vardenafil (Levitra).
We have known since 2003 that this longer half-life provides a therapeutic window of 36 hours.1 Recently, studies have shown that tadalafil's longer half-life lends itself to once-daily dosing as well. 2-7 Steady-state plasma concentrations are attained within five days of initiating daily dosing. 8 Based on its pharmacokinetics, after five days of once-daily dosing, the plasma concentration of tadalafil achieved with a 2.5 mg and 5 mg daily dose is 4 mg and 8 mg, respectively.
The FDA announced approval for once-daily dosing of tadalafil in January 2008, adding an option in the clinician's armamentarium against ED that unlinks the temporal association between a medication and the sexual encounter.
The new dosing schedule of tadalafil prompted us to write this updated review of its use in the treatment of ED. In the review we also briefly discuss ED, the physiology of penile erection, and the role of PDE5, before focusing exclusively on tadalafil and comparing it with its PDE5 inhibitor counterparts.
In addition to its latest clinical studies, the review includes the historical development of tadalafil as a PDE5 inhibitor first called IC351 in 1993 that was initially tested as a cardiovascular drug, as well as a comprehensive report of its pharmacology. The studies highlighted in the review include tadalafil in the general ED population, difficult-to-treat ED, ED secondary to diabetes mellitus, and ED after prostate cancer treatment.
Tadalafil is a safe, well-tolerated, and efficacious treatment for all severities and etiologies of ED, and its half-life of 17.5 hours lends itself to a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations with once-daily dosing.
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online pharmacy viagra (Cialis), one of the three available phosphodiesterase type 5 (PDE5) inhibitors that revolutionized the treatment of erectile dysfunction (ED), analyzes its latest clinical studies. Tadalafil's most unique and identifying characteristic is its long half-life of 17.5 hours, compared with 4 hours for sildenafil (Viagra) and vardenafil (Levitra).
We have known since 2003 that this longer half-life provides a therapeutic window of 36 hours.1 Recently, studies have shown that tadalafil's longer half-life lends itself to once-daily dosing as well. 2-7 Steady-state plasma concentrations are attained within five days of initiating daily dosing. 8 Based on its pharmacokinetics, after five days of once-daily dosing, the plasma concentration of tadalafil achieved with a 2.5 mg and 5 mg daily dose is 4 mg and 8 mg, respectively.
The FDA announced approval for once-daily dosing of tadalafil in January 2008, adding an option in the clinician's armamentarium against ED that unlinks the temporal association between a medication and the sexual encounter.
The new dosing schedule of tadalafil prompted us to write this updated review of its use in the treatment of ED. In the review we also briefly discuss ED, the physiology of penile erection, and the role of PDE5, before focusing exclusively on tadalafil and comparing it with its PDE5 inhibitor counterparts.
In addition to its latest clinical studies, the review includes the historical development of tadalafil as a PDE5 inhibitor first called IC351 in 1993 that was initially tested as a cardiovascular drug, as well as a comprehensive report of its pharmacology. The studies highlighted in the review include tadalafil in the general ED population, difficult-to-treat ED, ED secondary to diabetes mellitus, and ED after prostate cancer treatment.
Tadalafil is a safe, well-tolerated, and efficacious treatment for all severities and etiologies of ED, and its half-life of 17.5 hours lends itself to a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations with once-daily dosing.
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понедельник, 23 мая 2011 г.
EVOLUCIÓN DE UN DELITO QUE AMENAZA LA SALUD PÚBLICA
La mafia de la Viagra
Pocos productos reúnen tantos activos para ser falsificados como una pastilla de cheap viagra, cialis o cualquier fármaco contra la disfunción eréctil. Son medicamentos caros, que precisan de receta médica y que no todo el mundo puede tomar (no se receta a personas con cardiopatÃas). Además, muchas personas no están dispuestas a reconocer ante el médico que tienen problemas de ereccióny mucho menos a hacérselo saber a un farmacéutico. Asà que no son pocos los que caen en la tentación de comprar esas medicinas por internet arriesgándose a una intoxicación y alimentando asà la maquinaria de la falsificación de medicamentos, una actividad ilÃcita que organismos como la ONU y policÃas como los Mossos d'Esquadra califican ya como una "actividad criminal global de primera magnitud".
El sistema de venta está organizado en torno a un complejo entramado de páginas web en las que algunas funcionan únicamente como franquicias anunciadoras que remiten a otras páginas madre, alojadas en servidores de paraÃsos informáticos. Las primeras son identificables pero su actividad no es punible. Determinar la jurisdicción sobre las segundas, que son las que realmente se saltan la ley, es ardua tarea. La distribución corre a cargo de células aisladas que manejan solamente dos o tres tipos de fármaco cada una.
Los medicamentos falsos más demandados en paÃses occidentales son aquellos asociados al estilo de vida. No son fármacos para tratar patologÃas graves, sino más bien destinados a problemas comola disfunción eréctil, el sobrepeso, la caÃda del cabello o a potenciar la musculatura(esteroides). Los expertos aclaran que esto se debe, entre otras cosas, al hecho de que son paÃses donde los tratamientos de enfermedades de enjundia resultan accesibles en mayor o menor grado. Esos productos falsificados adquiridos a través de la web rara vez contienen el principio activoque prometen y, si lo hacen, suele ser en una cantidad muy baja. A veces al analizarlos se hallan incluso componentes dañinos.
Los médicos también alertan de la proliferación de remedios supuestamente milagrosos que carecen por completo de base cientÃfica (como es el caso de un extracto de veneno de escorpión que se anuncia como cura contra el cáncer y protección contra los efectos secundarios de la quimioterapia). Asimismo, han detectado que se comercializan productos supuestamente "naturales"que en realidad deben sus efectos a que incluyen componentes farmacológicos.
вторник, 3 мая 2011 г.
Trust your libido to our solutions
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- It is not true that sexual order cialis is unavoidable part of getting older. There are many reasons that can make your sexual life difficult, among them can be quite unexpected like mental health as well as physical health and your sexual experience can affect your ability to be sexualy active in any age. Sexually transmitted diseases can cause later impact on erectile function, usually people with STD have riskier life style and multiple partners experience. To help the patients fight the adverse side effects of all those conditions there have been developed a number of efficient erectile cheap cialis drugs.
- A well known diamond shaped pill, for one, is used to regulate sexual problems in men, such as erectile dysfunction caused by various factors. It is an oral drug that comes in form of a tablet meant to be taken once a day directly before the planned sexual contact.
- The pill starts producing its medicinal effects between 30 minutes and one hour (the exact uptake period may vary from patient to patient or else it may be different depending on the actual patient�s condition). The effects of this drug may still be felt 6 hours later after the moment of the intake, which makes it so popular. The patients are reported to experience accelerated recharge periods in the course of their Sildenafil therapy. There is every evidence of the fact that the magic blue pill acts not only as a reliable erectile solution, but as a potential stamina booster as well.
- Make sure that you have no medical contraindications before you start taking erecile dysfunction pills; here belong heart problems, cardiovascular disease, and some other conditions.
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Call for papers for Clinical Medicine: Therapeutics from Dr Garry Walsh
I am writing to you in my capacity as the Editor-in-Chief of Clinical cheap cialis: Therapeutics. It is a great pleasure to invite you to submit an article to the Journal.Clinical cheap cialis: Therapeutics provides a rapid forum for the dissemination of original research papers and review articles focused on the role of therapeutics in clinical medicine in terms of efficacy, outcomes, safety and programs for the sustained use of medicines.
I am interested in receiving concise reports of clinical studies in all therapeutic areas together with those that address our current understanding of disease pathology and management. Interesting single-case reports that inform the effective treatment of patients are also welcome. Of particular interest are submissions that investigate or review the implications of treatments that are disease modifying rather than symptomatic.
The journal competes head-on with a number of existing subscription-based journals. However, there is clearly a niche for the new journal. The reason for this is because all journal articles will be accessible without any access boundaries to all internet users throughout the world.
Another major benefit of open access online journals is that anyone can contribute, and not only those in major institutions. These freedoms are coupled with rigorous, fair and prompt standards of peer review. I hope to receive your contribution to this exiting new journal in the near future.
What is the advantage to you of publishing in Clinical Medicine: Therapeutics?
- Full open access: everyone can read your article and you retain copyright in it
- Publishing decision within 2 weeks of submission
- Your paper will not be rejected due to lack of space and will be published immediately on acceptance
- Prompt and fair peer review from two expert peer reviewers
- Frequent updates on your paper’s status
- Friendly responsive staff
Clinical Medicine: Therapeutics is a journal that publishes papers in efficacy, outcomes, safety and programs for the sustained use of medicines.
What a previous author said:
"The communication between your staff and me has been terrific. Whenever progress is made with the manuscript, I receive notice. Quite honestly, I've never had such complete communication with a journal."In summary:
The advantages of a younger journal such as Clinical Medicine: Therapeutics are numerous but in essence allow us a greater flexibility and responsiveness to authors and readers that older journals cannot match.
Next steps:
- Visit the journal's home page (full open access to all articles)
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Yours sincerely,
Dr Garry Walsh
Editor-in-Chief
Clinical Medicine: Therapeutics
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